Activity of Fusidic Acid against Methicillin-resistant Staphylococcus Aureus (mrsa) Isolated from Cf Patients

Poster # 285 INTRODUCTION RESULTS 2011 NACFC, Anaheim, CA Prabhavathi Fernandes, Ph.D. 6340 Quadrangle Drive, Suite 100 Chapel Hill, North Carolina 27517 [email protected] The potential clinical impact of MRSA in the pathogenesis of CF is gaining increased attention. Studies have shown that pulmonary function declines with MRSA infection and the mortality rate is increased among MRSA-positive patients. These observations and the expected continued emergence of resistance emphasize the need for effective strategies to prevent and treat MRSA colonization/infection in CF. Foremost among these include the availability of  The clinical impact of MRSA in the pathogenesis of Cystic Fibrosis (CF) has gained increased attention MRSA positive subjects had greater rates of decline of FEV1 and required more antibiotic treatment A collaborative study of CF centers in the US showed the pathologic importance of MRSA in CF (Dasenbrook 2010)  19,833 patients aged 6 45 years showed the association b i MRSA i l d i l Drug MIC Range